img.wp-smiley,img.emoji {display: inline !important;border: none !important;box-shadow: none !importa"/> img.wp-smiley,img.emoji {display: inline !important;border: none !important;box-shadow: none !importa"/>
Thalidomide binds to the E3 ubiquitin ligase complex formed between cereblon (CRBN), damaged DNA binding protein 1 (DDB1), and Cul4A inhibiting ligase activity. Inhibits TNF synthesis and FGF-induced angiogenesis. Thalidomide initiates its teratogenic effects by binding to CRBN and inhibiting the associated ubiquitin E3 ligase activity. Cell permeable.
Purity | >98% (TLC); NMR (Conforms) |
Quantity | 100 mg, 200 mg |
Molecular Weight | 258.2 Da |
Physical State | White powder |
Solubility | DMSO (5 mg/ml) |
CAS No. | |
Storage | 4°C, (-20°C Long term). Store solutions at -20°C for up to three months. The product can be shipped at room temperature. |
LifeSensors成立于1996年,位于美国宾夕法尼亚州费城,是一家为药物发现与研究提供方法和可行性技术方法的生物技术公司。公司致力于为泛素和泛素蛋白酶体通路研究领域提供高品质的抗体、酶、蛋白质等试剂和试剂盒,产品最全、最新,是泛素研究者的最佳选择。其原核和真核蛋白表达系统SUMOpro和SUMOstar已被世界范围内的学术、政府研究机构和制药、生物技术公司广泛应用。通过提供创新的研究工具,LifeSensors已成为泛素和泛素样蛋白途径的领导者。