Specifications

Functionalized von-Hippel-Lindau protein ligand (VHL) for PROTAC research and development; incorporates an E3 ligase ligand plus a PEG linker ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D.

Product Information

Purity:                               >95%MW:                                   700.29Formula:                           C32H49N5O8S.HClCAS Number                    2064292-52-8Physical State:                  Lyophilized white solidQuantity:                          5mg or 10mg; 25mgSolubility:                         70 mg/mL in DMSO; 70 mg/mL in waterStorage:                            Store at -20C.

References

1. Zengerle et al (2015) Selective small molecule induced degradation of the BET bromodomain protein BRD4. ACS Chem. Biol. 10 1770 PMID: 260356252. Salami et al (2017) Waste disposal-An attractive strategy for cancer therapy. Science 355 1163 PMID: 283028253. Chan et al (2018) Impact of target warhead and linkage vector on inducing protein degradation: comparison of bromodomain and extra-terminal (BET) degraders derived from triazolodiazepine (JQ1) and tetrahydroquinoline (I-BET726) BET inhibitor scaffolds. J.Med.Chem. 61 504 PMID: 28595007

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